Underreported Threat of Multidrug-Resistant Tuberculosis in Africa
Author Information
Author(s): Ben Amor Yanis, Nemser Bennett, Singh Angad, Sankin Alyssa, Schluger Neil
Primary Institution: Columbia University
Hypothesis
MDR TB rates in Africa may be more prevalent than previously appreciated.
Conclusion
The study suggests that the threat of multidrug-resistant tuberculosis in Africa is likely higher than previously reported.
Supporting Evidence
- MDR TB rates must be assessed in countries without these surveys.
- Retreatment failure rate was the most predictive indicator for MDR TB.
- Current category II drug regimens may increase MDR TB.
Takeaway
The study found that there might be more cases of drug-resistant tuberculosis in Africa than we thought, and we need to check more countries to understand the real situation.
Methodology
Data were gathered from WHO reports and peer-reviewed journals, and analyzed using correlation and linear regression models.
Potential Biases
The accuracy of reporting may be biased due to the low number of countries participating in drug resistance surveys.
Limitations
The study was limited by differing country-level data estimates and the ecologic study design.
Participant Demographics
The study included data from 39 of the 46 countries in the AFRO region.
Statistical Information
P-Value
0.043
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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