Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma
2008
Identifying Cancer Stem Cells in Glioblastoma After Radiation
publication
Evidence: moderate
Author Information
Author(s): Kang Mi K, Hur Beong I, Ko Mi H, Kim Cheul H, Cha Seung H, Kang Soo K
Primary Institution: Pusan National University
Hypothesis
Is cellular radio-resistance a characteristic associated with cancer stem cells in glioblastoma?
Conclusion
The study provides evidence for the existence of radio-resistant subpopulations of cancer stem cells in glioblastoma, which may contribute to tumor growth and recurrence.
Supporting Evidence
- Radio-resistant cancer cell subpopulations express specific surface markers like CD133 and CD117.
- These subpopulations can initiate tumor formation when transplanted into mice.
- Radio-resistant cells show similarities to hematopoietic stem cells.
Takeaway
Some brain cancer cells can survive radiation and act like stem cells, which helps them grow back into tumors.
Methodology
The study involved developing a dissociated cell system from glioblastoma to analyze radio-resistant cancer stem cell subpopulations.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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