HomoMINT: A Human Protein Interaction Network
Author Information
Author(s): Maria Persico, Arnaud Ceol, Caius Gavrila, Robert Hoffmann, Arnaldo Florio, Gianni Cesareni
Primary Institution: Department of Biology, University of Rome Tor Vergata
Hypothesis
Can we infer a human protein interaction network using data from model organisms?
Conclusion
The HomoMINT network contains 9749 inferred interactions between 4125 human proteins, providing a resource for analyzing protein interactions.
Supporting Evidence
- The HomoMINT network is based on interactions from model organisms mapped to human orthologs.
- Approximately one fifth of the interactions in the MINT database could be mapped to human orthologs.
- The inferred network is updated daily to include new interactions curated in the MINT database.
Takeaway
Scientists created a big map showing how human proteins might interact, using information from other animals.
Methodology
The study used the InParanoid algorithm to map interactions from model organisms to human proteins and filtered orthology assignments based on domain architecture.
Potential Biases
The network may be biased due to the selective interest of the scientific community in certain biological domains.
Limitations
The inferred network may contain false positives and is limited by the quality of the original model organism datasets.
Participant Demographics
The study focused on human proteins and their interactions inferred from model organisms.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website