Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect?
2000
Effect of Cimetidine on Tumor Cell Growth in Breast Cancer
publication
Author Information
Author(s): Bowrey P F, King J, Magarey C, Schwartz P, Marr P, Bolton E, Morris D L
Primary Institution: UNSW Department of Surgery and Department of Histopathology, The St George Hospital, Kogarah, Sydney NSW 2217, Australia
Hypothesis
Does preoperative cimetidine administration have an effect on tumor cell proliferation in breast cancer?
Conclusion
Preoperative cimetidine administration does not influence tumor cell proliferation in breast cancer.
Supporting Evidence
- Endogenous histamine affects growth mechanisms in experimental mammary carcinomas.
- 75% of malignant carcinomas express H2 receptors.
- Cimetidine influences tumor infiltrating lymphocytes in colorectal cancer but not in breast cancer.
- Tumor cell proliferation is measured by Ki-67 antibody labeling.
Takeaway
This study looked at whether a medication called cimetidine could help slow down cancer growth in breast tumors, but it found that it doesn't make a difference.
Digital Object Identifier (DOI)
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