Factors Associated with In-Hospital Mortality in Adult Patients with Bacterial Meningitis
Author Information
Author(s): Makowiecki Michał, Paciorek Marcin, Bednarska Agnieszka, Krogulec Dominika, Porowski Dawid, Bursa Dominik, Skrzat-Klapaczyńska Agata, Bieńkowski Carlo, Kowalska Justyna D., Zielenkiewicz Magdalena, Horban Andrzej, Laskus Tomasz, Fedson David S.
Primary Institution: Medical University of Warsaw
Hypothesis
The study aims to evaluate the association between various clinical and laboratory findings and in-hospital mortality in community-acquired bacterial meningitis.
Conclusion
Survivors and non-survivors with bacterial meningitis differed in several clinical signs, symptoms, and laboratory results, with specific scoring systems showing high associations with in-hospital deaths.
Supporting Evidence
- 56 patients (16.5%) died during hospitalization.
- Non-survivors had a lower Glasgow Coma Scale score and higher SOFA score.
- Streptococcus pneumoniae was more common in non-survivors.
- Patients who died were more likely to be immunocompromised.
- Lower frequency of headache and nausea/vomiting was observed in non-survivors.
Takeaway
This study looked at patients with bacterial meningitis and found that those who died had different symptoms and test results compared to those who survived.
Methodology
The study retrospectively analyzed clinical and laboratory data of adult patients with bacterial meningitis admitted to a hospital over a period of eight years.
Potential Biases
Potential bias due to retrospective data collection and reliance on medical records.
Limitations
The study only evaluated in-hospital mortality and did not follow up with patients after discharge.
Participant Demographics
Adult patients (≥18 years old) with community-acquired bacterial meningitis.
Statistical Information
P-Value
p<0.001
Confidence Interval
OR 95% CI 0.59–0.75 for GCS; OR 95% CI 1.29–1.60 for SOFA
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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