Prognostic Factors in Phase I Cancer Trials
Author Information
Author(s): Tirelli U
Primary Institution: National Cancer Institute
Hypothesis
Can patients with prostate cancer who are not pretreated with chemotherapy have better outcomes in phase I trials compared to those who are pretreated?
Conclusion
Patients with prostate cancer who were not pretreated with chemotherapy had significantly better outcomes than those with non-urological cancers.
Supporting Evidence
- 54 patients (25%) had prostate cancer.
- 37 patients (68%) were not pretreated with chemotherapy.
- Patients with urological cancers had better outcomes than those with non-urological cancers.
Takeaway
This study found that prostate cancer patients who didn't have chemotherapy before a trial did better than those who did.
Methodology
Analysis of outcomes from 29 phase I trials involving 212 patients.
Limitations
The study does not compare outcomes between pretreated and non-pretreated prostate cancer patients directly.
Participant Demographics
54 patients (25%) had prostate cancer, 37 (68%) were not pretreated with chemotherapy.
Statistical Information
P-Value
0.001
Statistical Significance
p=0.001
Digital Object Identifier (DOI)
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