OrthoList: A Compendium of C. elegans Genes with Human Orthologs
Author Information
Author(s): Shaye Daniel D., Greenwald Iva
Primary Institution: Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
Hypothesis
We sought to assess the orthology between C. elegans and human genes to understand better the relationship between their genomes.
Conclusion
OrthoList will be of considerable utility to C. elegans researchers for streamlining RNAi screens by focusing on genes with apparent human orthologs.
Supporting Evidence
- OrthoList contains 7,663 C. elegans protein-coding genes.
- OrthoList has extensive coverage with low false-positive and false-negative rates.
- Virtually all conserved hits from genome-wide RNAi screens would have been obtained using just the OrthoList set.
Takeaway
The study created a list of C. elegans genes that are similar to human genes, which can help scientists do experiments more easily.
Methodology
A meta-analysis of results from four orthology prediction programs was performed to compile a list of C. elegans genes with human orthologs.
Limitations
The accuracy of orthology predictions may depend on the quality of gene models in the genomes under scrutiny.
Digital Object Identifier (DOI)
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