Understanding Tetracycline Resistance in Enterobacterales
Author Information
Author(s): Muacevic Alexander, Adler John R, Flores Hannah, Luethy Paul, Doub James B
Primary Institution: University of Maryland Medical Center
Hypothesis
Can susceptibility to minocycline and third-generation tetracyclines be inferred from other tetracycline classes in Enterobacterales?
Conclusion
Tigecycline can be used to infer susceptibility to omadacycline and eravacycline, but minocycline susceptibility cannot be inferred when resistance to doxycycline and tetracycline is present.
Supporting Evidence
- All clinical isolates were resistant to tetracycline and doxycycline.
- 30% of E. coli and E. cloacae isolates were non-susceptible to minocycline.
- All isolates were susceptible to eravacycline and omadacycline.
Takeaway
This study looked at how some bacteria resist certain antibiotics and found that while some newer antibiotics can still work, we can't assume that minocycline will work just because other antibiotics do.
Methodology
The study used clinical isolates of E. coli, K. pneumoniae, and E. cloacae to assess susceptibility to various tetracyclines through Kirby-Bauer and microbroth dilution assays.
Limitations
The sample size was small and only included three species of Enterobacterales, limiting the generalizability of the findings.
Participant Demographics
Clinical isolates from E. coli, K. pneumoniae, and E. cloacae resistant to tetracycline and doxycycline.
Digital Object Identifier (DOI)
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