Maternal Characteristics and HIV RNA at Delivery
Author Information
Author(s): Izzo Ilaria, Forleo Maria A, Casari Salvatore, Quiros-Roldan Eugenia, Magoni Michele, Carosi Giampiero, Torti Carlo
Primary Institution: Institute of Infectious and Tropical Disease, University of Brescia, Brescia, Italy
Hypothesis
In migrant women, the risk of detectable HIV RNA at delivery is greater owing to late HIV diagnosis.
Conclusion
The study highlights the need for extensive HIV screening and earlier antiretroviral therapy for pregnant women, especially migrants.
Supporting Evidence
- 26.9% of women had detectable HIV RNA at delivery.
- Migrant women presented later and had lower CD4+ counts than Italians.
- Early initiation of antiretroviral therapy is crucial for reducing HIV RNA levels.
Takeaway
This study found that many pregnant women with HIV don't know they are infected, which can lead to risks for their babies. It's important to test and treat them early.
Methodology
A retrospective observational study using univariate and multivariable regression analyses to assess factors associated with detectable HIV RNA at delivery.
Potential Biases
Potential biases due to retrospective data collection and missing information on HIV drug resistance and viral subtypes.
Limitations
The study was retrospective, had a small sample size, and lacked HIV RNA data for some women.
Participant Demographics
154 pregnant women, 46.8% migrants, with varying geographical origins including Italy and Africa.
Statistical Information
P-Value
p = 0.003; p < 0.0001; p = 0.038
Confidence Interval
RR = 1.86; RR = 4.3; RR = 0.94
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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