Canadian Highly Sensitized Patient Program Report: A 1000 Kidney Transplants Story
Author Information
Author(s): M. Khaled Shamseddin, Steven Paraskevas, Rahul Mainra, Kyle Maru, Bailey Piggott, Darlene Jagusic, Kathy Yetzer, Lakshman Gunaratnam, Christine Ribic, Joseph Kim, Sunita Singh, Stephanie Hoar, G. V. Ramesh Prasad, Melanie Masse, Isabelle Houde, Myriam Khalili, Kenneth West, Rob Liwski, Sean Martin, Nessa Gogan, Martin Karpinski, Mauricio Monroy-Cuadros, Sita Gourishankar, Olwyn Johnston, James Lan, Christopher Nguen, John Gill, Michel Pâquet
Primary Institution: Canadian Blood Services
Hypothesis
The Canadian HSP Program aims to increase transplant opportunities for highly sensitized patients by prioritizing them in kidney allocation systems.
Conclusion
The Canadian HSP Program has successfully facilitated 1000 kidney transplants for highly sensitized patients who may not have received transplants otherwise.
Supporting Evidence
- 70% of active transplant candidates enrolled in the HSP Program were in the hardest to match group (cPRA ≥99%).
- Only 22% of transplant candidates with cPRA of 100% have received a transplant to date through the Program.
- The average time from first participation in the Canadian HSP Program to transplantation for cPRA ≥99% recipients was significantly longer than for cPRA 95% to 98% recipients.
- By the end of June 2024, the Canadian HSP Program had facilitated 1000 transplants, 613 of which were from interprovincial matches.
- The average cold ischemic time for interprovincial transplants was significantly longer compared to intraprovincial transplants.
Takeaway
This study shows that a special program helped many people with hard-to-match kidney needs get transplants they wouldn't have been able to get before.
Methodology
The study involved a retrospective review of data from the Canadian Transplant Registry to evaluate the impact of the Canadian HSP Program on kidney transplants.
Potential Biases
Potential bias due to incomplete data capture in the registry.
Limitations
The study is limited by its retrospective nature and the lack of available short- and long-term clinical outcomes data.
Participant Demographics
Participants were predominantly female (62%) with an average age of 50 years.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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