Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1
2011
Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1
publication
Evidence: moderate
Author Information
Author(s): Ramakrishnan Rajesh, Yu Wendong, Rice Andrew P
Primary Institution: Baylor College of Medicine
Hypothesis
What are the sets of genes whose levels are regulated by either Cyclin T2 or Cyclin T1?
Conclusion
The study suggests that there is limited redundancy in genes regulated by Cyclin T1 or Cyclin T2.
Supporting Evidence
- 292 genes were down-regulated by depletion of Cyclin T2.
- 631 genes were down-regulated by depletion of Cyclin T1.
- 100 genes were commonly reduced in either knockdown.
- 111 and 287 genes were up-regulated when either Cyclin T2 or Cyclin T1 was depleted, respectively.
Takeaway
The researchers looked at how two proteins, Cyclin T1 and Cyclin T2, control different genes in cells, and found that they don't overlap much in what they control.
Methodology
The study used shRNA lentiviral vectors to deplete Cyclin T1 and Cyclin T2 in HeLa cells and performed cDNA microarray analysis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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