Developing New Anthelmintics from Plant Cysteine Proteinases
Author Information
Author(s): Jerzy M Behnke, David J Buttle, Gillian Stepek, Ann Lowe, Ian R Duce
Primary Institution: School of Biology, University of Nottingham
Hypothesis
Can naturally occurring cysteine proteinases from plants be developed into effective anthelmintics for treating intestinal worm infections?
Conclusion
The study suggests that plant-derived cysteine proteinases have significant potential as novel anthelmintics against intestinal helminths.
Supporting Evidence
- Plant cysteine proteinases have been used traditionally for treating worm infections.
- Some plant extracts have shown effectiveness against human intestinal worms in historical reports.
- Recent studies indicate that papaya latex can significantly reduce worm burdens in infected mice.
Takeaway
This study looks at how certain plant proteins can help get rid of worms in animals and humans, which is important because some medicines aren't working anymore.
Methodology
The study reviews existing literature on the efficacy of plant cysteine proteinases against various helminths and discusses their potential as anthelmintics.
Limitations
The study notes that many plant-derived compounds have not been rigorously tested and may not compete effectively with synthetic drugs.
Digital Object Identifier (DOI)
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