Mouse Model of Factor X Deficiency Shows Maternal Transfer of Factor X
Author Information
Author(s): TAI S J, HERZOG R W, MARGARITIS P, ARRUDA V R, CHU K, GOLDEN J A, LABOSKY P A, HIGH K A
Primary Institution: The Children’s Hospital of Philadelphia
Hypothesis
Can very low levels of factor X activity rescue embryonic and perinatal lethality in mice?
Conclusion
Minimal factor X activity levels as low as 1–3% are sufficient to rescue lethality in mice.
Supporting Evidence
- F10 knockout mice showed embryonic or perinatal lethality.
- Homozygous Friuli mice had sufficient factor X activity to rescue lethality.
- Maternal transfer of factor X was suggested to improve embryonic survival.
Takeaway
Scientists created special mice that can survive with very little factor X, a protein important for blood clotting, showing that even tiny amounts can help babies grow.
Methodology
The study involved creating knockout mice and analyzing their survival and factor X activity levels.
Limitations
The study primarily focuses on a specific genetic model and may not fully represent human conditions.
Participant Demographics
Mice used in the study were genetically modified to study factor X deficiency.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website