Hepatitis E Virus Infection in Women with Gynecological Tumors
Author Information
Author(s): Bai Wenye, Wu Xiao, Zhao Shuchao, Yu Yang, Wang Zhongjun, Li Xiu, Zhou Na
Primary Institution: The Affiliated Hospital of Qingdao University
Hypothesis
Is there a correlation between hepatitis E virus infection and gynecological tumors in women?
Conclusion
Patients with gynecological tumors are more susceptible to hepatitis E virus infection, especially those with ovarian borderline tumors.
Supporting Evidence
- 69 out of 452 patients with gynecological tumors tested positive for anti-HEV antibodies.
- 15.27% of patients with gynecological tumors were seropositive compared to 5.09% of healthy controls.
- Contact with dogs and a history of chemotherapy were identified as independent risk factors for HEV infection.
Takeaway
Women with certain types of tumors are more likely to get a virus called hepatitis E, especially if they have had chemotherapy or have dogs.
Methodology
The study involved 452 women with gynecological tumors and 452 healthy controls, measuring anti-HEV antibodies through enzyme-linked immunoassays over a median follow-up of 5.4 years.
Potential Biases
Potential false positives from ELISA diagnostic equipment; limited generalizability due to sample size.
Limitations
The sample size was relatively small and may not represent the entire Chinese population; HEV RNA tests were not conducted to confirm infection status.
Participant Demographics
Participants included women aged 21-69, with 452 diagnosed with gynecological tumors and 452 healthy controls.
Statistical Information
P-Value
0.001
Confidence Interval
[1.10–3.22]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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