Withania somnifera Gel Helps Heal Inflammatory Bowel Disease
Author Information
Author(s): Pankaj Pawar, Suhit Gilda, Siddhesh Sharma, Suresh Jagtap, Anant Paradkar, Kakasaheb Mahadik, Prabhakar Ranjekar, Abhay Harsulkar
Primary Institution: Poona College of Pharmacy, Bharati Vidyapeeth University, Pune, India
Hypothesis
Can Withania somnifera root extract in a rectal gel formulation reduce inflammation and promote healing in inflammatory bowel disease?
Conclusion
The rectal gel containing Withania somnifera showed significant healing effects in rats with inflammatory bowel disease.
Supporting Evidence
- The extract showed 95.6% inhibition of lipid peroxidation at the highest concentration tested.
- Histopathological studies indicated restoration of intestinal features comparable to healthy intestines.
- WSRE treatment resulted in significant decrease in malondialdehyde levels, indicating reduced oxidative stress.
Takeaway
This study found that a gel made from a plant called Withania somnifera can help heal a sick gut in rats.
Methodology
The study involved preparing a gel from Withania somnifera root extract, testing its antioxidant activity, and evaluating its effects in a rat model of inflammatory bowel disease.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Wistar rats weighing approximately 200-250 g of either sex.
Statistical Information
P-Value
0.0411
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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