Anti-Inflammatory Effects of Moringa oleifera Extract
Author Information
Author(s): Luetragoon Thitiya, Daowtak Krai, Thongsri Yordhathai, Potup Pachuen, Calder Philip C., Usuwanthim Kanchana
Primary Institution: Naresuan University
Hypothesis
Can Moringa oleifera extract and its component 3-hydroxy-β-ionone reduce inflammation in endothelial cells?
Conclusion
Moringa oleifera extract and 3-hydroxy-β-ionone significantly reduce inflammation in endothelial cells by inhibiting the NF-κB signaling pathway.
Supporting Evidence
- Moringa oleifera extract significantly decreased levels of pro-inflammatory mediators like IL-6, IL-8, and MCP-1.
- 3-hydroxy-β-ionone reduced the expression of adhesion molecules ICAM-1 and VCAM-1 in endothelial cells.
- Pre-treatment with Moringa extract decreased monocyte adhesion and transmigration across endothelial cells.
Takeaway
Moringa leaves can help reduce inflammation in blood vessels, which is good for heart health.
Methodology
The study used EA.hy926 endothelial cells treated with TNF-α and Moringa oleifera extract to assess inflammation markers and monocyte adhesion.
Limitations
Only a single dose of extracts was tested, and the study was conducted in vitro.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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