Common Regulatory Mechanisms in Human and Mouse Bimodal Genes
Author Information
Author(s): Ertel Adam, Tozeren Aydin
Primary Institution: Drexel University
Hypothesis
Do human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality?
Conclusion
Bimodal genes are enriched in cell membrane and extracellular environment proteins, indicating their potential as biomarkers for tissue specificity.
Supporting Evidence
- 14% of human genes were identified as bimodal.
- More than 40% of bimodal human genes have mouse orthologs.
- Enriched KEGG pathways include ECM-receptor interaction and focal adhesion.
Takeaway
This study found that some genes behave like switches in both humans and mice, helping cells communicate better.
Methodology
The study used microarray data to identify bimodal genes in human and mouse, applying a two-component mixture model for analysis.
Potential Biases
Potential bias from using different microarray platforms and tissue types.
Limitations
The study may not account for all variations in gene expression due to differences in tissue types and microarray platforms.
Participant Demographics
Human and mouse tissue samples were analyzed.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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