The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis
2006
The role of CD164 in prostate cancer metastasis
Sample size: 600
publication
Evidence: moderate
Author Information
Author(s): A.M. Havens, Y. Jung, Y.X. Sun, J. Wang, R.B. Shah, H.J. Bühring, K.J. Pienta, R.S. Taichman
Primary Institution: University of Michigan
Hypothesis
Prostate cancer cells may use the CXCL12/CXCR4 axis to home to bone marrow.
Conclusion
CD164 may play an important role in localizing prostate cancer cells to the marrow.
Supporting Evidence
- CD164 expression was positively correlated with prostate-specific antigen levels.
- Blocking CD164 reduced prostate cancer cell adhesion to bone marrow endothelial cells.
- CD164 expression was greater in bone metastases than in primary tumors.
Takeaway
This study found that a protein called CD164 helps prostate cancer cells move to the bone, which is where they often spread.
Methodology
The study used prostate cancer cell lines and human tissue microarrays to analyze CD164 expression and its role in adhesion and invasion.
Participant Demographics
Patients who underwent radical retro pubic prostatectomy for prostate cancer.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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