Loss of protection with insecticide-treated nets against pyrethroid-resistant Culex quinquefasciatus mosquitoes once nets become holed: an experimental hut study
2008

Effect of Holes in Insecticide-Treated Nets on Mosquito Protection

Sample size: 1265 publication 10 minutes Evidence: moderate

Author Information

Author(s): Irish SR, N'Guessan R, Boko PM, Metonnou C, Odjo A, Akogbeto M, Rowland M

Primary Institution: London School of Hygiene and Tropical Medicine

Hypothesis

The study investigates whether pyrethroid-treated nets lose their protective capacity against pyrethroid-resistant Culex quinquefasciatus mosquitoes as they become holed.

Conclusion

As nets deteriorate with use and become increasingly holed, the capacity of pyrethroid treatments to restore protection is greatly diminished against resistant Culex quinquefasciatus mosquitoes.

Supporting Evidence

  • The proportion of mosquitoes blood feeding increased significantly when untreated nets became holed.
  • Treated nets showed a significant increase in blood feeding rates as the number of holes increased.
  • The insecticide treatment provided limited protection against blood feeding in holed nets.

Takeaway

When mosquito nets get holes, they don't work as well to keep mosquitoes out, especially if the mosquitoes are resistant to the chemicals in the nets.

Methodology

The study used experimental huts to test intact and holed insecticide-treated and untreated nets against Culex quinquefasciatus mosquitoes.

Potential Biases

Potential bias in mosquito collection methods and environmental factors affecting mosquito behavior.

Limitations

The study was limited to a specific geographic area and mosquito species, which may not represent all contexts.

Participant Demographics

Six adult men participated as sleepers in the experimental huts.

Statistical Information

P-Value

0.026

Confidence Interval

29.4–43.5

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1756-3305-1-17

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