Study of 17beta-HSD2 in Human Placenta During Pregnancy
Author Information
Author(s): Renée Drolet, Marc Simard, Julie Plante, Philippe Laberge, Yves Tremblay
Primary Institution: Centre Hospitalier Universitaire de Québec
Hypothesis
17beta-HSD2 regulates estradiol levels in fetal circulation during pregnancy.
Conclusion
The study shows that 17beta-HSD2 acts as a barrier to decrease estradiol secretion rates in fetal circulation.
Supporting Evidence
- 17beta-HSD2 mRNA levels increased by 2.27 fold from mid-gestation to term.
- 17beta-HSD2 protein levels were 30 to 60 fold higher in term placenta compared to endometrium.
- High levels of estradiol were found in term placenta compared to endometrium.
Takeaway
This study looks at how a specific enzyme in the placenta helps control the amount of a hormone called estradiol that reaches the baby during pregnancy.
Methodology
The study used RT-QPCR to quantify mRNA levels and immunohistochemistry to study protein expression in placental tissues.
Participant Demographics
Women undergoing voluntary termination of pregnancy and those delivering at term.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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