Distribution and Reactivity of Myocrisin
Author Information
Author(s): W. Ewen Smith, John Reglinski
Primary Institution: Department of Pure and Applied Chemistry, University of Strathclyde
Hypothesis
Can the therapeutic effectiveness of gold compounds be improved through a better understanding of their chemistry?
Conclusion
The study suggests that the distribution and reactivity of myocrisin differ significantly from other gold compounds, indicating potential for improved therapeutic outcomes.
Supporting Evidence
- The concentration of gold in plasma accumulates in a saw tooth pattern during myocrisin therapy.
- Gold binds mainly to albumin and y-globulin in the blood.
- High concentrations of gold are found in organs like the kidney, liver, and spleen.
- Gold can be detected long after cessation of myocrisin therapy.
- Gold may modulate cell function by interacting with transport proteins in cell membranes.
Takeaway
Myocrisin is a gold compound used to treat rheumatoid arthritis, and understanding how it works in the body could help make it safer and more effective.
Methodology
The study involved comparative analysis of gold distribution in patients receiving myocrisin therapy, using techniques like electrophoresis and atomic absorption spectrometry.
Limitations
Not all patients completed the treatment course, and sample collection timing varied.
Participant Demographics
Patients with aggressive rheumatoid arthritis undergoing myocrisin therapy.
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