Lactobacillus paracasei Enhances Asthma Treatment
Author Information
Author(s): Alwayli Dhafer, Jiang Xiaoli, Liang Jiaxu, Shah Syed Rafiq Hussain, Ullah Atta, Abusidu Mohammed F. Z., Shu Wen, Barabutis Nektarios
Primary Institution: Dalian Medical University
Hypothesis
Can Lactobacillus paracasei improve the effectiveness of sublingual immunotherapy in asthmatic mice?
Conclusion
The combination of Lactobacillus paracasei with sublingual immunotherapy significantly reduces allergic symptoms and inflammation in asthmatic mice.
Supporting Evidence
- Mice receiving the combined treatment showed a significant reduction in rubbing frequency.
- Serum IgE levels decreased significantly in the combined treatment group.
- Anti-inflammatory cytokines like IFN-γ and IL-10 increased after treatment.
- Pro-inflammatory cytokines IL-17 and TNF-α were reduced in the combined treatment group.
- Lung inflammation was significantly mitigated in the combined treatment group.
Takeaway
This study shows that giving a probiotic called Lactobacillus paracasei along with allergy treatment can help mice with asthma feel better.
Methodology
Allergic asthma was induced in Balb/c mice, followed by treatment with sublingual immunotherapy and Lactobacillus paracasei, with various immune parameters evaluated.
Limitations
The study was conducted in a mouse model, and results may not directly translate to humans.
Participant Demographics
Male BALB/c mice, aged six to eight weeks.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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