Global Distribution of Novel Rhinovirus Genotype
Author Information
Author(s): Briese Thomas, Renwick Neil, Venter Marietjie, Jarman Richard G., Ghosh Dhrubaa, Köndgen Sophie, Shrestha Sanjaya K., Hoegh A. Mette, Casas Inmaculada, Adjogoua Edgard Valerie, Akoua-Koffi Chantal, Myint Khin Saw, Williams David T., Chidlow Glenys, van den Berg Ria, Calvo Cristina, Koch Orienka, Palacios Gustavo, Kapoor Vishal, Villari Joseph, Dominguez Samuel R., Holmes Kathryn V., Harnett Gerry, Smith David, Mackenzie John S., Ellerbrok Heinz, Schweiger Brunhilde, Schønning Kristian, Chadha Mandeep S., Leendertz Fabian H., Mishra A.C., Gibbons Robert V., Holmes Edward C., Lipkin W. Ian
Primary Institution: Columbia University
Hypothesis
Is the novel rhinovirus genotype associated with community outbreaks and pediatric respiratory disease globally?
Conclusion
The novel rhinovirus genotype is globally distributed and associated with community outbreaks of acute respiratory illness and severe lower respiratory tract infections in infants.
Supporting Evidence
- The novel rhinovirus genotype was found in respiratory samples from multiple continents.
- It was associated with community outbreaks of acute respiratory illness.
- The study identified the novel genotype in 34% of all detected picornavirus infections.
Takeaway
Scientists found a new type of cold virus that is making people sick all over the world, especially kids. This virus has been around for a long time and is causing a lot of respiratory illnesses.
Methodology
The study used multiplex MassTag PCR to analyze respiratory samples from various countries.
Limitations
The study may have sampling errors due to the limited number of samples and the short sequence available for analysis.
Participant Demographics
Samples were collected from symptomatic children and adults across various age groups in multiple countries.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% HPD = 0.3–14.6 × 10–4 substitutions/site/y
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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