Noninvasive Brain Stimulation in Primates
Author Information
Author(s): Lybbert Carter, Webb Taylor, Wilson Matthew G., Tsunoda Keisuke, Kubanek Jan
Primary Institution: University of Utah
Hypothesis
The pulse repetition frequency of the ultrasonic stimulation should be a key factor in modulating the responses.
Conclusion
This new method can be used to transiently inhibit evoked neural activity in deep brain regions of primates.
Supporting Evidence
- Ultrasound focused into the LGN evoked a robust increase in gamma activity.
- Low pulse repetition frequencies suppressed evoked gamma activity.
- The method allows for focal electrical stimulation of deep brain circuits without invasive electrode implantation.
Takeaway
Scientists used sound waves to change how brain cells work in monkeys without surgery, and found that lower sound frequencies can calm brain activity.
Methodology
The study applied a combination of magnetic and focused ultrasonic fields to deep brain visual circuits in two non-human primates and quantified the electroencephalographic gamma activity evoked in the visual cortex.
Potential Biases
The effects observed may be influenced by the anesthesia used during the experiments.
Limitations
The study was conducted under anesthesia, which may influence neural responses.
Participant Demographics
Two adult male rhesus non-human primates, both 10 years old.
Statistical Information
P-Value
7.00×10−4
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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