SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury
2011
SDF1 and CXCR4 in Spinal Cord Injury
publication
Evidence: moderate
Author Information
Author(s): Vicki M Tysseling, Divakar Mithal, Vibhu Sahni, Derin Birch, Hosung Jung, Richard J Miller, John A Kessler
Primary Institution: Northwestern University's Feinberg School of Medicine
Hypothesis
How do SDF1 and CXCR4 signaling affect cell migration after spinal cord injury?
Conclusion
SDF1 attracts CXCR4+ macrophages to the site of spinal cord injury, which may help regulate the inflammatory response.
Supporting Evidence
- SDF1 is expressed in the dorsal corticospinal tract and meninges.
- CXCR4 expression increases significantly after spinal cord injury.
- CXCR4+ macrophages migrate towards SDF1 sources after injury.
Takeaway
After a spinal cord injury, a special signal helps certain cells move to the injury site to help heal it.
Methodology
The study used transgenic mice to examine SDF1 and CXCR4 expression in the spinal cord before and after injury.
Digital Object Identifier (DOI)
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