Probiotic Fermented Milk Improves Gut and Immune Health in Malnourished Mice
Author Information
Author(s): Galdeano Carolina Maldonado, Núñez Ivanna Novotny, de Moreno de LeBlanc Alejandra, Carmuega Esteban, Weill Ricardo, Perdigón Gabriela
Primary Institution: Centro de Referencia para Lactobacilos (CERELA-CONICET)
Hypothesis
The study aims to evaluate the effects of probiotic fermented milk on gut health and systemic immunity in a model of non-severe protein-energy malnutrition in mice.
Conclusion
Probiotic fermented milk significantly improved gut microbiota and enhanced immune responses in malnourished mice, providing protection against Salmonella infection.
Supporting Evidence
- Probiotic fermented milk improved the intestinal microbiota in malnourished mice.
- It increased the number of immune cells like IgA+ cells and macrophages.
- The study showed enhanced systemic immune response against OVA antigen.
- Probiotic milk reduced the spread of Salmonella in infected mice.
- Histological analysis showed improved intestinal structure after re-nutrition with probiotic milk.
- Phagocytic activity of macrophages was significantly increased with probiotic milk.
- Continuous administration of probiotic milk was necessary for sustained immune response.
- Probiotic fermented milk was more effective than non-fat milk or bacterial free supernatant.
Takeaway
Giving sick mice a special yogurt helped them get better and fight off germs better.
Methodology
Mice were divided into groups receiving different diets, including probiotic fermented milk, and their immune responses and gut health were evaluated after re-nutrition.
Potential Biases
Potential conflicts of interest due to funding from a company that produces the probiotic.
Limitations
The study was conducted on a specific mouse model, which may not fully represent human malnutrition.
Participant Demographics
BALB/c mice, both malnourished and well-nourished controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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