The Role of MTSS1 in Oesophageal Cancer
Author Information
Author(s): Xie Fei, Ye Lin, Chen Jinfeng, Wu Nan, Zhang Zhiqian, Yang Yue, Zhang Lijian, Jiang Wen G
Primary Institution: Cardiff University School of Medicine, Cardiff, UK and Peking University School of Oncology, Beijing, China
Hypothesis
What is the clinical significance of MTSS1 in oesophageal squamous cell carcinoma?
Conclusion
MTSS1 may serve as a potential prognostic indicator in human oesophageal squamous cell carcinoma and could be an important target for cancer therapy.
Supporting Evidence
- MTSS1 expression was down-regulated in oesophageal tumour tissues and cancer cell lines.
- High levels of MTSS1 transcripts were associated with better overall survival.
- MTSS1 expression correlated with tumour grade and lymph node metastasis.
Takeaway
MTSS1 is a protein that helps control cancer growth, and having more of it can mean better survival for patients with oesophageal cancer.
Methodology
The study assessed MTSS1 expression in tumours and adjacent non-tumour tissues from 105 ESCC patients and evaluated its influence on cancer cell behavior.
Limitations
The study was limited to a specific cohort of oesophageal cancer patients and may not be generalizable to all cancer types.
Participant Demographics
87 men and 18 women, average age 58.75 years.
Statistical Information
P-Value
p = 0.024, p = 0.010, p = 0.035
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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