Breast Cancer and Hormone Replacement Therapy in Danish Women
Author Information
Author(s): Stahlberg C, Pedersen A T, Andersen Z J, Keiding N, Hundrup Y A, Obel E B, Møller S, Rank F, Ottesen B, Lynge E
Primary Institution: University of Copenhagen, Denmark
Hypothesis
Does the current use of different hormone replacement therapy (HRT) types and regimens influence the risk of developing breast cancers with various prognostic characteristics?
Conclusion
Current use of hormone replacement therapy increases the risk of being diagnosed with both favorable and unfavorable breast cancers.
Supporting Evidence
- 25.1% of women in the cohort were current users of HRT.
- 244 women developed invasive breast cancer during the observation period.
- Current HRT users had a multivariate relative risk of 2.49 for invasive ductal carcinoma compared to never users.
Takeaway
Women using hormone replacement therapy have a higher chance of getting breast cancer, but the type of cancer can vary.
Methodology
The study analyzed data from the Danish nurse cohort, focusing on breast cancer cases among postmenopausal women and their HRT usage.
Potential Biases
Potential detection bias due to increased surveillance in HRT users.
Limitations
The study may have biases related to detection and surveillance, and it lacks updated exposure information over time.
Participant Demographics
Natural postmenopausal women, primarily Danish nurses.
Statistical Information
P-Value
0.013
Confidence Interval
1.76–3.51
Statistical Significance
p=0.013
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website