Effect of L. plantarum cell-free extract and co-trimoxazole against Salmonella Typhimurium: a possible adjunct therapy
2011
Combining Probiotic Extract with Antibiotic to Fight Salmonella
publication
Evidence: moderate
Author Information
Author(s): Rishi Praveen, Preet Simran, Kaur Prabhjot
Primary Institution: Department of Microbiology, Panjab University, Chandigarh, India
Hypothesis
Can the cell-free extract of L. plantarum enhance the efficacy of co-trimoxazole against Salmonella Typhimurium?
Conclusion
The combination of L. plantarum cell-free extract and co-trimoxazole shows enhanced antimicrobial efficacy against Salmonella Typhimurium.
Supporting Evidence
- The combination reduced the required concentration of both agents to achieve the same antibacterial effect.
- Significantly higher intracellular killing of Salmonella was observed with the combination treatment.
- The FIC index indicated a synergistic effect when both agents were used together.
Takeaway
Using a probiotic extract together with an antibiotic can help fight off a type of bacteria called Salmonella better than using either one alone.
Methodology
The study evaluated the synergistic effect of L. plantarum cell-free supernatant and co-trimoxazole through various in-vitro and ex-vivo assays.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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