Evaluating Meningococcal Disease Vaccination Impact
Author Information
Author(s): J Jaime Caro, Jörgen Möller, Denis Getsios, Laurent Coudeville, Wissam El-Hadi, Catherine Chevat, Van Hung Nguyen, Ingrid Caro
Primary Institution: Caro Research Institute
Hypothesis
What is the potential impact of routine vaccination of adolescents with a quadrivalent conjugate vaccine on invasive meningococcal disease in the United States?
Conclusion
Routine vaccination of adolescents can significantly reduce the incidence of invasive meningococcal disease and its associated health consequences.
Supporting Evidence
- Routine vaccination can reduce life years lost due to invasive disease by over 45%.
- Without vaccination, 2,807 cases of meningococcal disease are predicted annually.
- Vaccination at 70% coverage can prevent 1,100 cases annually due to herd immunity.
- Life years lost due to infection drop from over 14,000 to 7,600 with routine vaccination.
- Routine vaccination is expected to reduce outbreaks by 74%.
Takeaway
Vaccinating kids can help stop the spread of a serious disease called meningococcal disease, which can make people very sick.
Methodology
A discrete event simulation was developed to model the epidemiology of invasive meningococcal disease and assess the impact of routine vaccination.
Potential Biases
Potential biases may arise from the assumptions made regarding vaccine effectiveness and herd immunity.
Limitations
The model relies on assumptions about herd immunity and does not account for variations in community characteristics.
Participant Demographics
The simulation is based on a US population with a starting size of 200,000 individuals, reflecting age and gender distributions.
Digital Object Identifier (DOI)
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