Bone Health in Older Men with Type 2 Diabetes
Author Information
Author(s): Moira A Petit, Misti L Paudel, Brent C Taylor, Julie M Hughes, Elsa S Strotmeyer, Ann V Schwartz, Jane A Cauley, Joseph M Zmuda, Andrew R Hoffman, Kristine E Ensrud
Primary Institution: University of Minnesota
Hypothesis
Men with T2DM would have lower bone strength relative to their body weight, particularly in highly trabecular regions such as the distal radius and distal tibia.
Conclusion
Older men with T2DM have lower bone strength relative to body weight at cortical sites despite having higher bone density.
Supporting Evidence
- Men with T2DM had greater bone volumetric density but smaller bone area.
- Higher bone density compensated for lower bone area, resulting in no difference in compressive bone strength at trabecular sites.
- At cortical sites, men with T2DM had lower bone bending strength relative to body weight.
Takeaway
This study found that older men with diabetes have strong bones in some areas but weaker bones in others, which could lead to more fractures.
Methodology
The study used peripheral quantitative computed tomography (pQCT) to assess bone density and strength in older men with and without T2DM.
Potential Biases
Self-reporting of diabetes diagnosis may introduce bias.
Limitations
The study did not assess the duration or severity of diabetes and was limited to a predominantly white male population.
Participant Demographics
The majority of participants were Caucasian men aged 65 and older.
Statistical Information
P-Value
p < .05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website