Ocular Surface Disease in Graves’ Orbitopathy
Author Information
Author(s): Maglionico Maria Novella, Lanzolla Giulia, Figus Michele, Cosentino Giada, Comi Simone, Marinò Michele, Santini Ferruccio, Posarelli Chiara
Primary Institution: University of Pisa and University Hospital of Pisa, Pisa, Italy
Hypothesis
This study aims to assess the presence of ocular surface disease in patients with Graves' disease and moderate-to-severe active Graves' orbitopathy compared to those with mild non-active Graves' orbitopathy.
Conclusion
Patients with moderate-to-severe active Graves' orbitopathy have a significantly higher prevalence of ocular surface disease compared to those with mild non-active disease.
Supporting Evidence
- OSDI scores were significantly higher in patients with moderate-to-severe active GO compared to those with mild non-active GO.
- A cutoff value of 33 for positive tests revealed a higher frequency of pathological OSDI in moderate-to-severe active GO patients.
- There was a significant positive correlation between OSDI and Clinical Activity Score (CAS) in the moderate-to-severe active GO group.
- Proptosis values ≥ 22 mm and the presence of lagophthalmos were identified as significant risk factors for ocular surface disease development.
Takeaway
This study found that people with a more severe form of Graves' disease have worse eye problems, showing that the severity of the disease affects eye health.
Methodology
A cross-sectional study design was used to evaluate ocular surface disease using the Ocular Surface Disease Index (OSDI) in patients with Graves' disease and different severities of Graves' orbitopathy.
Potential Biases
The study may have subjective bias due to reliance on self-reported OSDI scores.
Limitations
The study's cross-sectional design limits the ability to establish causal relationships, and a formal sample size calculation was not performed before the study.
Participant Demographics
The study included 79 patients, with 57 having moderate-to-severe active Graves' orbitopathy and 22 with mild non-active Graves' orbitopathy.
Statistical Information
P-Value
P=0.0006
Confidence Interval
95% CI 1.277-9.531
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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