Disease Extent ≥4 cm as a Prognostic Marker in Breast Cancer
Author Information
Author(s): D. Lindquist, D. Hellberg, T. Tot
Primary Institution: Central Hospital Falun, Sweden
Hypothesis
Is disease extent evaluated by large-section histology a prognostic marker for local recurrence in breast cancer patients treated with breast-conserving surgery?
Conclusion
A disease extent of 4 cm or more is an important factor for predicting local recurrence in breast cancer patients.
Supporting Evidence
- A disease extent ≥4 cm was shown to be an independent marker for local recurrence.
- The cumulative 10-year local relapse rate for the group with a disease extent ≥4 cm was 20.5%.
- Statistical analysis showed significant differences in local recurrence rates based on disease extent.
Takeaway
If a breast cancer tumor is bigger than 4 cm, it might come back after treatment, so doctors need to pay extra attention to it.
Methodology
The study evaluated disease extent in surgical specimens using large-section histology and correlated it with local recurrence rates.
Potential Biases
Potential biases due to the retrospective nature and selection of patients.
Limitations
The study is retrospective and the treatment guidelines have changed since the time of the study.
Participant Demographics
All participants were women diagnosed with invasive or in situ breast carcinomas treated with breast-conserving surgery.
Statistical Information
P-Value
0.001
Confidence Interval
1.41–103.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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