Cod Extract Reduces Heart Failure Mortality in Mice
Author Information
Author(s): Omerovic Elmir, Linbom Malin, Råmunddal Truls, Lindgård Ann, Undeland Ingrid, Sandberg Ann-Sofie, Soussi Bassam
Primary Institution: Wallenberg Laboratory at Sahlgrenska Academy, Göteborg University
Hypothesis
Can an aqueous low molecular weight extract from cod muscle decrease acute mortality in a mouse model of heart failure caused by doxorubicin?
Conclusion
The aqueous low molecular weight cod muscle extract decreases mortality in the mouse model of doxorubicin-induced acute heart failure.
Supporting Evidence
- Mortality rate was 68% lower in the mice treated with the extract.
- The cod extract showed strong antioxidative effects in vitro.
- Echocardiography confirmed the presence of acute heart failure in treated mice.
Takeaway
This study found that a special fish extract can help mice live longer after getting a heart problem from a cancer treatment.
Methodology
Male BALB/c mice were treated with doxorubicin and either cod extract or saline, and their survival was monitored over two weeks.
Limitations
The study did not compare the cod extract's efficacy to other known cardioprotective agents and did not demonstrate specific cardioprotective effects in terms of cardiac function.
Participant Demographics
Male BALB/c mice, approximately 25 grams in weight.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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