How O-GlcNAcylation Affects Pyroptosis
Author Information
Author(s): Lang Yue, Li Jincheng, Zhang Leiliang
Primary Institution: Shandong First Medical University
Hypothesis
O-GlcNAcylation modulates the signaling pathways of pyroptosis, potentially influencing inflammatory responses in various diseases.
Conclusion
O-GlcNAcylation plays a significant role in regulating pyroptosis and may serve as a therapeutic target for managing inflammatory diseases.
Supporting Evidence
- O-GlcNAcylation of GSDMD reduces pyroptosis by inhibiting its interaction with caspase-4.
- High glucose levels increase O-GlcNAcylation of GSDME, promoting macrophage pyroptosis.
- O-GlcNAcylation stabilizes NLRP3, enhancing its role in pyroptosis.
- O-GlcNAcylation of NEK7 promotes its interaction with NLRP3, facilitating pyroptosis.
- O-GlcNAcylation of NF-κB influences inflammatory responses and NLRP3 activation.
Takeaway
O-GlcNAcylation is like a switch that can turn on or off a type of cell death called pyroptosis, which is important for fighting infections but can also cause problems if not controlled.
Methodology
This review synthesizes findings from various studies on the role of O-GlcNAcylation in pyroptosis-related proteins.
Limitations
The review does not provide original experimental data and relies on existing literature, which may have varying methodologies and results.
Digital Object Identifier (DOI)
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