Fra-1 and CD44 in Human Mesotheliomas
Author Information
Author(s): Maria E Ramos-Nino, Steven R Blumen, Harvey Pass, Brooke T Mossman
Primary Institution: University of Vermont College of Medicine
Hypothesis
The increased expression of Fra-1 in the AP-1 complex causes the activation of target genes that influence malignancy and invasion of human MMs.
Conclusion
Fra-1 is associated with cell migration in human mesotheliomas and modulates CD44 expression, which may govern the migration of selected mesotheliomas.
Supporting Evidence
- Fra-1 expression was found in 33 of 34 human mesotheliomas.
- All CD44+ tumors were SV40-.
- Silencing Fra-1 or CD44 significantly reduced cell migration in mesothelioma cell lines.
Takeaway
This study found that a protein called Fra-1 helps cancer cells called mesotheliomas move around by affecting another protein called CD44.
Methodology
The study used various human mesothelioma cell lines and examined the effects of silencing Fra-1 on CD44 expression and cell migration.
Participant Demographics
Human mesothelioma cell lines derived from patients.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website