Do septins have a role in cancer?
2005
The Role of Septins in Cancer
publication
Evidence: moderate
Author Information
Author(s): Russell S E H, Hall P A
Primary Institution: Centre for Cancer Research & Cell Biology, Queen's University Belfast
Hypothesis
Do septins have a role in cancer?
Conclusion
Septins are involved in cancer through alterations in their expression profiles and complex splicing patterns.
Supporting Evidence
- Alterations in septin expression are seen in human diseases including neoplasia.
- SEPT9 has been linked to neoplasia through various studies.
- SEPT4 may also be involved in neoplasia, with specific isoforms promoting apoptosis.
Takeaway
Septins are special proteins that help cells divide and can change in cancer, which might help tumors grow.
Methodology
This review summarizes the properties of septins and their involvement in human neoplasia based on existing literature.
Limitations
The complexity of septin gene expression and splicing makes it difficult to fully understand their roles in cancer.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website