Oxidative Stress in Hepatitis C Infected Hemodialysis Patients
Author Information
Author(s): Horoz Mehmet, Bolukbas Cengiz, Bolukbas Filiz F, Aslan Mehmet, Koylu Ahmet O, Selek Sahbettin, Erel Ozcan
Primary Institution: Harran University, School of Medicine
Hypothesis
Does hepatitis C infection impact oxidative stress in hemodialysis subjects?
Conclusion
Hepatitis C infection does not cause an additional increase in oxidative stress in hemodialysis subjects.
Supporting Evidence
- Total antioxidant capacity was significantly higher in controls than in hemodialysis subjects.
- Total peroxide level and oxidative stress index were significantly lower in controls.
- Hepatitis C negative hemodialysis subjects had higher total antioxidant capacity compared to hepatitis C positive subjects.
Takeaway
This study looked at how hepatitis C affects the stress on the body in patients on dialysis. It found that having hepatitis C doesn't make the stress worse than in those without it.
Methodology
The study included 16 hepatitis C positive and 24 negative hemodialysis subjects, along with 24 healthy controls, measuring total antioxidant capacity, total peroxide level, and oxidative stress index.
Potential Biases
Potential bias due to the exclusion of patients with certain conditions and the reliance on a single measurement of oxidative stress.
Limitations
The study only measured one oxidative stress marker and did not account for other potential markers or sequential measurements.
Participant Demographics
Participants included 16 hepatitis C positive and 24 negative hemodialysis patients, with a mix of genders and various underlying causes of end-stage renal disease.
Statistical Information
P-Value
p<0.05/3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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