Regulation and function of the extracellular matrix protein tenascin-C in ovarian cancer cell lines
1999
Role of Tenascin-C in Ovarian Cancer
publication
Author Information
Author(s): Wilson K E, Bartlett J M S, Miller E P, Smyth J F, Mullen P, Miller W R, Langdon S P
Primary Institution: ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
Hypothesis
The study investigates the regulation and function of tenascin-C in ovarian cancer cell lines.
Conclusion
Tenascin-C is overexpressed in ovarian cancer and plays a role in cell adhesion and migration.
Supporting Evidence
- Tenascin-C is overexpressed in the stroma of malignant ovarian tumors.
- Concentrations of secreted tenascin-C were significantly higher in ovarian fibroblast cell lines compared to carcinoma cell lines.
- Transforming growth factor (TGF)-β1 was found to stimulate tenascin-C secretion.
- The SKOV-3 cell line showed increased migration through tenascin-C compared to a control protein.
Takeaway
Tenascin-C is a protein that helps ovarian cancer cells stick and move, which might help them spread.
Methodology
The study used various ovarian cancer cell lines to assess the secretion and functional role of tenascin-C.
Digital Object Identifier (DOI)
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