Liver-Derived IGF-I Regulates Mean Life Span in Mice
Author Information
Author(s): Svensson Johan, Sjögren Klara, Fäldt Jenny, Andersson Niklas, Isaksson Olle, Jansson John-Olov, Ohlsson Claes
Primary Institution: Sahlgrenska University Hospital, Göteborg, Sweden
Hypothesis
Is specific deficiency of liver-derived, endocrine IGF-I important for life span?
Conclusion
Adult inactivation of liver-derived, endocrine IGF-I resulted in moderately increased mean life span.
Supporting Evidence
- LI-IGF-I-/- mice had a 10% longer mean life span compared to control mice.
- Female LI-IGF-I-/- mice lived 16% longer than female control mice.
- Body weight and body fat decreased in LI-IGF-I-/- mice.
Takeaway
Mice with less liver-derived IGF-I lived longer, especially the females, because they had less body fat and used energy better.
Methodology
The study involved creating transgenic mice with liver-specific IGF-I inactivation and measuring their life span, body weight, and gene expression.
Limitations
The study did not perform necropsies to assess specific stress or disease signs in the mice.
Participant Demographics
The study involved male and female mice, with specific focus on the effects of liver-derived IGF-I on life span.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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