Triple Therapy Improves Survival in Burn and Smoke Inhalation Injury
Author Information
Author(s): Asmussen S, Yamamoto Y, Traber DL, Ito H, Cox R, Hawkins H, Traber LD, Herndon D, Enkhbaatar P
Primary Institution: University of Texas Medical Branch, Galveston, TX, USA
Hypothesis
This triple therapy decreases the requirement of ventilation, reduces ventilation days and improves survival.
Conclusion
The triple therapy may be a novel and efficient therapeutic alternative to improve the outcome of burn patients with smoke inhalation injury.
Supporting Evidence
- All treated sheep survived and were weaned from the ventilator.
- Four out of five treatment sheep could be decannulated from the tracheostomy tube at 72 hours.
- Only three out of five control sheep survived 96 hours.
Takeaway
The study tested a new treatment for sheep with severe burns and smoke inhalation, and it helped them breathe better and survive.
Methodology
Ten female sheep were randomly allocated to control or treatment groups, with the treatment group receiving a combination of rhAT, heparin, and tPA.
Participant Demographics
Ten female sheep, average weight 34.4 kg.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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