Breast cancer risk in ataxia telangiectasia heterozygotes
Author Information
Author(s): Janin N, Andrieu N, Ossian K, Laugé A, Croquette M-F, Griscelli C, Debré M, Bressac-de-Paillerets B, Aurias A, Stoppa-Lyonnet D
Primary Institution: Institut Gustave Roussy
Hypothesis
Do ataxia telangiectasia heterozygotes have an increased risk of breast cancer?
Conclusion
The study found a significant increase in breast cancer risk among obligate ATM heterozygotes.
Supporting Evidence
- The relative risk of breast cancer was assessed using French estimated incidence rates.
- A significant increase risk of breast cancer was found among obligate ATM heterozygotes with a point estimate of 3.32.
- Breast cancer relative risk is significantly increased among obligate ATM heterozygotes female relatives aged 44 years or younger.
Takeaway
People who carry a specific genetic change related to ataxia telangiectasia may have a higher chance of getting breast cancer.
Methodology
Family data was collected, including demographic characteristics and cancer occurrences, and DNA samples were analyzed using microsatellite markers.
Limitations
The increased risk is only slightly higher than classical reproductive risk factors.
Participant Demographics
French families with ataxia telangiectasia.
Statistical Information
P-Value
0.002
Statistical Significance
p=0.002
Digital Object Identifier (DOI)
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