L-Selectin and Atherosclerosis in Mice
Author Information
Author(s): Rozenberg Izabela, Sluka Susanna H. M., Mocharla Pavani, Hallenberg Anders, Rotzius Pierre, Borén Jan, Kränkel Nicolle, Landmesser Ulf, Borsig Lubor, Lüscher Thomas F., Eriksson Einar E., Tanner Felix C.
Primary Institution: University of Zurich
Hypothesis
Deletion of L-selectin might attenuate the development of atherosclerosis due to inhibition of leukocyte rolling and capture.
Conclusion
The absence of L-selectin does not inhibit atherosclerosis but rather increases the early stages of the disease.
Supporting Evidence
- ApoE−/− L-sel−/− mice had a two-fold increase in atherosclerotic lesions compared to ApoE−/− controls after 6 weeks on a high cholesterol diet.
- Increased numbers of circulating lymphocytes were observed in L-sel−/− mice.
- No significant differences in leukocyte rolling were found between the two mouse strains.
Takeaway
Mice without a protein called L-selectin had more heart artery problems early on, showing that this protein actually helps protect against these issues.
Methodology
The study involved crossing L-selectin deficient mice with ApoE deficient mice and analyzing atherosclerosis development under different diet conditions.
Participant Demographics
Mice used in the study were male and included both L-selectin deficient and ApoE deficient strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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