Circadian Rhythm of the Autonomic Nervous System in Insulin Resistant Subjects
Author Information
Author(s): Perciaccante Antonio, Fiorentini Alessandra, Paris Alberto, Serra Pietro, Tubani Luigi
Primary Institution: University 'La Sapienza', Rome, Italy
Hypothesis
Insulin resistance might be related to sympathetic over-activity and that dysautonomia increases if insulin resistance is associated with glucose metabolic impairment.
Conclusion
Insulin resistance may cause global autonomic dysfunction that increases with worsening glucose metabolic impairment.
Supporting Evidence
- The total SDNN showed statistically significant reduction in all four groups with insulin resistant subjects when compared to the control group.
- During night, LF normalized units were found to be higher in all four groups including IR subjects than in the control group.
- The linear regression model demonstrated direct association between LF values and the homeostasis model assessment-index (HOMA-I).
Takeaway
This study found that people with insulin resistance have problems with their body's automatic functions, especially at night, which can lead to heart issues.
Methodology
Heart rate variability was measured using 24-hour ECG recordings in insulin resistant subjects and control subjects.
Limitations
The study used the HOMA-index as a conventional indicator of insulin resistance, which may not be the best method.
Participant Demographics
100 Caucasian subjects, including 51 men and 29 women, aged approximately 51 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website