DRED: A Database for Genes Related to Repeat Expansion Diseases
Author Information
Author(s): Shi Qingqing, Dai Min, Ma Yingke, Liu Jun, Liu Xiuying, Wang Xiu-Jie
Primary Institution: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Hypothesis
The study aims to develop a comprehensive database for genes associated with repeat expansion diseases.
Conclusion
DRED serves as a central resource for researchers and clinicians to access information on genes related to repeat expansion diseases.
Supporting Evidence
- DRED includes 61 known genes related to repeat expansion diseases.
- The database also predicts 516 additional genes that may cause diseases via repeat expansion.
- DRED provides links to external resources like NCBI and ClinVar.
- The database is user-friendly and frequently updated.
Takeaway
DRED is like a big library that helps scientists find information about genes that can cause certain diseases when they repeat too much.
Methodology
The database was created by manually curating information from PubMed and OMIM, and using machine learning to predict potential disease-causing genes.
Limitations
The database may not include all possible genes related to repeat expansion diseases as it relies on existing literature and predictions.
Digital Object Identifier (DOI)
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