Pharmacokinetics of Maritime Pine Bark Extract in Healthy Volunteers
Author Information
Author(s): Tanja Grimm, Roswitha Skrabala, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdeňka Ďuračková, Petra Högger
Primary Institution: Bayerische Julius-Maximilians-Universität, Würzburg, Germany; Comenius University, Faculty of Medicine, Bratislava, Slovakia
Hypothesis
What are the plasma kinetics of maritime pine bark extract and its metabolites after ingestion?
Conclusion
The study reveals that constituents and metabolites of Pycnogenol are bioavailable and detectable in plasma, with the identification of ten unknown compounds.
Supporting Evidence
- Plasma concentrations of catechin, caffeic acid, ferulic acid, taxifolin, and the metabolite M1 were quantified.
- Ten unknown compounds were detected in plasma after ingestion of Pycnogenol.
- The study provides the first pharmacokinetic analysis of Pycnogenol constituents in humans.
Takeaway
When people take maritime pine bark extract, their bodies absorb it and it can be found in their blood, showing that it might be helpful for health.
Methodology
Healthy volunteers ingested single and multiple doses of Pycnogenol, and plasma samples were analyzed using HPLC.
Potential Biases
Potential bias due to the small number of participants and the specific demographic.
Limitations
The study had a small sample size and focused only on specific compounds.
Participant Demographics
Healthy volunteers aged 18 to 30 years, including both males and females.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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