Rotavirus P[4]G2 in a Vaccinated Population, Brazil
Author Information
Author(s): Linhares Alexandre C., Velázquez F. Raúl
Primary Institution: Ministério da Saúde, Belém, Pará, Brazil
Hypothesis
The predominance of P[4]G2 strains in Aracaju is unrelated to vaccine use.
Conclusion
The study suggests that the live, oral, attenuated human rotavirus vaccine can protect against the predominance of P[4]G2 rotaviruses despite low vaccine coverage.
Supporting Evidence
- Children <1 year of age showed a reduced risk for severe rotavirus diarrhea among vaccinated patients compared with nonvaccinated patients.
- The vaccine does not afford complete protection against infection, but it can protect against the predominance of P[4]G2.
- In a large phase III trial, a nonsignificant but protective trend was observed against severe disease associated with P[4]G2.
- Protection against P[4]G2 rotavirus gastroenteritis of any severity was 81% in a subsequent meta-analysis.
- The detection rate of rotavirus among severe diarrhea cases fell significantly after vaccine introduction.
Takeaway
This study looks at how a rotavirus vaccine works in kids in Brazil, showing it helps protect them even when some kids aren't vaccinated.
Methodology
The study involved comparing the incidence of severe rotavirus diarrhea in vaccinated and nonvaccinated children under 1 year of age.
Potential Biases
Potential misinterpretation of data regarding vaccine effectiveness due to low vaccine coverage.
Limitations
The study had a small sample size and a short surveillance period of only 4 months.
Participant Demographics
Children under 1 year of age in Aracaju, Brazil.
Statistical Information
P-Value
0.20
Confidence Interval
0.029–1.24
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website