Nickel-induced labial angioedema in a pediatric patient with orthodontic braces: a case report
2025

Nickel Allergy Causing Swelling in a Child with Braces

Sample size: 1 publication Evidence: low

Author Information

Author(s): Leone Fabrizio, Gori Alessandra, Cinicola Bianca Laura, Coletti Giorgio, Pignataro Elia, Martina Capponi, Giulia Brindisi, Anania Caterina, Zicari Anna Maria

Primary Institution: Sapienza University of Rome

Hypothesis

Can prolonged exposure to nickel from orthodontic devices trigger angioedema in susceptible individuals?

Conclusion

The removal of a nickel-containing orthodontic device led to the cessation of angioedema episodes in the patient.

Supporting Evidence

  • The patient had recurrent labial angioedema linked to nickel exposure.
  • Patch tests confirmed a significant allergy to nickel sulfate.
  • Symptoms resolved after the removal of the orthodontic device.

Takeaway

A girl had swelling in her lips because of braces made of nickel, and when the braces were taken out, the swelling stopped.

Methodology

Case report detailing the patient's history, allergy tests, and the effects of removing the orthodontic device.

Limitations

Unable to perform HLA typing and specific IgE tests for nickel.

Participant Demographics

12-year-old girl with a family history of nickel allergy.

Digital Object Identifier (DOI)

10.1186/s13052-024-01833-4

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