Sulcal Hyperintensity in Cerebral Amyloid Angiopathy–Related Inflammation
Author Information
Author(s): Larysa Panteleienko, Gargi Banerjee, Dermot Henry Mallon, Victoria Harvey, Rupert Oliver, Gary Hotton, William Knight, Sayan Datta, Michael S. Zandi, Hans Rolf Jäger, David John Werring
Primary Institution: UCL Queen Square Institute of Neurology, London, United Kingdom
Hypothesis
Can regions of sulcal hyperintensity serve as early imaging findings in patients with cerebral amyloid angiopathy-related inflammation who do not meet current diagnostic criteria?
Conclusion
Regions of sulcal hyperintensity can be an early imaging finding in cerebral amyloid angiopathy-related inflammation, potentially allowing for earlier diagnosis and treatment.
Supporting Evidence
- All 4 patients had regions of sulcal hyperintensity at clinical presentation.
- Three patients later developed asymmetric white matter hyperintensities with disease relapse.
- Two patients had pathologically proven cerebral amyloid angiopathy-related inflammation.
Takeaway
Doctors found that some patients with a brain condition called CAA-ri showed unusual areas in their brain scans that could help them get diagnosed faster.
Methodology
This is a case series from a specialist hospital intracerebral hemorrhage service.
Limitations
The study is based on a small number of cases, which may limit the generalizability of the findings.
Participant Demographics
Patients included 3 men and 1 woman, aged between 53 and 77 years.
Digital Object Identifier (DOI)
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