Infection of Bank Voles with Borna Disease Virus
Author Information
Author(s): Kinnunen Paula Maria, Inkeroinen Hanna, Ilander Mette, Kallio Eva Riikka, Heikkilä Henna Pauliina, Koskela Esa, Mappes Tapio, Palva Airi, Vaheri Antti, Kipar Anja, Vapalahti Olli
Primary Institution: University of Helsinki
Hypothesis
Can bank voles serve as a viral host for Borna disease virus (BDV) and how does the virus spread and transcribe its RNA into DNA in vivo?
Conclusion
Bank voles can be infected with BDV, leading to systemic infection and viral excretion without significant clinical disease.
Supporting Evidence
- BDV RNA and antigen were detectable in all infected voles.
- 54% of fecal samples were BDV RNA-positive.
- 66% of infected voles had BDV nucleocapsid gene DNA.
- Viral antigen was found in peripheral nerves and ganglia.
- Most infected voles remained asymptomatic.
Takeaway
Scientists found that bank voles can get a virus called BDV, which spreads in their bodies and can even change the virus's RNA into DNA, but most of the voles don't get sick.
Methodology
Neonate bank voles were infected with BDV intracerebrally and monitored for 2 to 8 weeks, followed by analysis of viral RNA and antigen in tissues.
Potential Biases
Potential bias in the selection of voles and the controlled laboratory environment may not reflect natural conditions.
Limitations
The study was limited to a small sample size and short observation period, which may not capture all potential outcomes.
Participant Demographics
Neonate bank voles from wild-caught parents.
Statistical Information
P-Value
p=0.055
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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